Synthesis Characterization and Bioactivity of Novel Pramipexole Schift base Metal Complexes.

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Author(s) T.Noorjahan Begum | R. MallikarjunaRao | A.Jayaraju | J.Sreeramulu
Pages 185-191
Volume 3
Issue 3
Date March, 2014
Keywords Synthesis, Characterization, Schiff base (2,4DHAPP), parmipexole, Biological activity

The synthesis and investigation of new Schiff base and its solid metal complexes derived from Pramipexole (4,5,6,7-Tetrahydro-N6-propyl,2,6-benzothiazolediamine) and 2,4-dihydroxy acetophonenone (2,4 DHAP) by using modified SandMayer’s method. The derived colored complexes are Cu (II) and Ru (II) with 2,4DHAPP. The structures of the titled new Schiff base were elucidated. Elemental analysis, IR, NMR, UV-Vis Spectrometry, ESR, TG-DTA and Conduct metric measurements. In addition the authors have been screened the compounds for biological activity. It was found that the compounds have shown activity against the organisms like Salmonella typhi, Enterococcus faecails and Escherichia coli.

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